Spyros Panagiotopoulos was born in Athens. During the mid '80s he studied classical percussion at Athens Conservatory and then he started his professional career performing and recording with the most notable Greek singers and composers. He has also performed with Prague Philharmonic Orchestra, the Russian Philharmonic and the Royal Philharmonic Orchestra of London.

In the early '90s he became one of the founding members of the group Page One and also a member of the "Jazz Club of the third program" a weekly show of the Greek Ρadio and Television (ERT). He has played with famous european and US jazz musicians such as Markus Stockhausen, Arild Andersen, Andy Sheppard, Bendik Hofseth, Sheila Jordan and Kevin Mahogany, as well as with considerable Greek artists such as Yiorgos Fakanas, Vasilis Rakopoulos and Dimitri Vassilakis.

In 2012 he formed the quintet BFAM (Brothers From Another Mother), which released its' debut "Happy Hour" in 2020. Since 1993 he has been teaching at various conservatories such as Philippos Nakas Conservatory and Athens Conservatory. He has also released an educational material on drums' technique.