Manos Theodosakis was born in Athens and studied classical trumpet, symphonic percussion and music theory at Zografou Municipality Conservatory, as well as jazz improvisation at Athenaeum Conservatory. As a classical music trumpet and music theory teacher he taught at Athenaeum Conservatory.

He has been a member of the Athens State Orchestra and has collaborated with all symphonic orchestras in Athens (ERT, Orchestra of Colours, Greek National Opera, etc.). He is a member of the City of Athens Big Band since 2000 and he has been its leader for six years.

He is a founding member of the band Jazz Police and has joined many groups of different music idioms: Pragma, Jazz Upstairs Big Band, Cubana Bop, Apurimac, Blues Bug, Locomondo, Desafinados, Savra ton Vasilikon Dromon and more.
He has collaborated with many artists of the jazz, rock and greek music scene.