Antonis Andreou was born in Lamia in 1981. He studied trombone, piano, and music theory at the local music school and later went on to earn his degree from the Philippos Nakas Conservatory. Among others he has also studied with Marc Nightingale, Jiggs Whigham and Wycliffe Gordon.

He was a a member of the European Jazz Orchestra and since 1999 has served as the lead trombonist of the Athens Big Band. He has toured and recorded with many artists, bands and orchestras including: the Symphonic Orchestra of Athens, Camerata string Orchestra, Olympic Games Orchestra 2004, Anthony Jackson, Horacio el Negro Hernandez, Dennis Chambers, Dave Weckl, Yiorgos Fakanas Group, Mike Stern, Bob Franceschini, Tony Lakatos, Alex Foster and Jeff Tain Watts and many more.

In 2013 he became a member of Pink Martini. Since 2007 he teaches trombone at the Yiorgos Fakanas' Art Music School.