Dimitris Zafeirelis was born in Athens. He started playing the guitar in various rock groups and gradually he turned his interest in to jazz, jazz-rock and classical music. He studied music theory with Alexandros Enian and classical guitar with Evagelos Asimakopoulos, as well as buzantine music at the National Conservatory of Athens.

Since the early '70s he has been collaborating with artists of various music idioms. He was a founding or active member of groups such as Among Jazz Point, Iraklis and Lernaia Ydra, Diplo Dueto, Igron Pyr, Trichordo, Jazz Indian Trio, Oriental X, Pan Guitar, Instrum & Vocal, Part 3, Amfionos Terpsis, mDuo, Harmonic Deos and he has performed at festivals, theaters and venues in Greece and abroad.

His first personal album "Leafage" was released in 1982. He has composed music for the theatre, for films as well as radio spots. He is also the author of many educational books and has written many articles for "Music" and "Tar" magazines.

He has been teaching at many conservatories and music schools and he has been active as member of the Board of Directors of Trade Unions such as the EMSE, Aftodiaheirisi and many organizations and festivals.