Alkis Karyzonis was born in Thessaloniki. He studied at the Department of Music of the Ionian University, the Department of Music Studies of Aristotle University of Thessaloniki, and the Macedonian Conservatory of Thessaloniki. He pursued postgraduate studies in composition at the Royal Conservatory of Brussels.

He has attended seminars with artists such as Steve Lacy, Sheila Jordan, Greg Osby, Evan Parker, Mark Abrams, and others.

He has performed in chamber music concerts in Belgium and Greece, has collaborated on numerous occasions with the National Theatre of Northern Greece (KTHBE), and has recorded with artists from a wide range of musical backgrounds.